Many stocks encountered turbulence this week, but few were blown about like several biotech stocks. Here are the three most horrendous performers in health care over the first week of June.
Underwhelming
Synta Pharmaceuticals (NASDAQ: SNTA ) announced results from a mid-stage clinical study this week for lung cancer drug ganetespib. Shares plunged�38% as investors reacted. Did the drug fail completely? Actually, no.
Patients taking a combination of�ganetespib and the chemotherapy�docetaxel�lived a median of 9.8 months. Other patients taking only docetaxel lived a median of 7.4 months. That's a 32% improvement. Even better improvement of 67% was experienced by patients whose cancer was diagnosed at least six months before the initiation of the study. Synta's results sound really good, right?
There are a couple of problems, though. First, results from the study announced late last year indicated more dramatic improvement. Second, the difference in numbers of patient deaths between the two groups of patients is small. Investors appear to be losing confidence that�ganetespib will live up to earlier expectations.
5 Best Media Stocks To Invest In 2015: ZELTIQ Aesthetics Inc (ZLTQ)
ZELTIQ Aesthetics, Inc. (ZELTIQ), incorporated on March 22, 2005, is a medical technology company. The Company is focused on developing and commercializing products utilizing its controlled-cooling technology platform. Its commercial product is the CoolSculpting System that reduces stubborn fat bulges. The Company generates revenues from capital sales of its CoolSculpting System and from procedure fees its physician customers pay for each CoolSculpting procedure they perform. As of March 31, 2011, it had an installed base of 346 and 475 CoolSculpting Systems worldwide and over 88,000 CoolSculpting procedures had been sold to its physician customers. The Company markets CoolSculpting to the dermatologists, plastic surgeons, and aesthetic specialists. As of March 31, 2011, ZELTIQ�� North American direct sales force consisted of 23 professionals, and over 88,000 CoolSculpting procedures were sold to ZELTIQ�� physician customers.
CoolSculpting System
ZELTIQ generates revenues from capital sales of its CoolSculpting System and from procedure fees its physician customers pay for each CoolSculpting procedure they perform. Capital sales of ZELTIQ�� CoolSculpting System include the CoolSculpting control unit and its CoolSculpting vacuum applicators. ZELTIQ generates procedure fees through sales of CoolSculpting procedure packs, which include its consumable gelpads and liners and a disposable computer cartridge that it markets as the CoolCard. The CoolCard contains enabling software that permits its physician customer to perform a fixed number of CoolSculpting procedures.
The CoolSculpting control unit is the base of the CoolSculpting System. ZELTIQ�� CoolSculpting control unit also contains software that tracks and collects data about each procedure performed and any error messages that may be generated during the procedure. CoolSculpting System includes three CoolSculpting vacuum applicators. ZELTIQ�� CoolSculpting procedure packs facilitate the pay-per-procedu! re feature of its CoolSculpting System. Its CoolSculpting procedure packs include CoolCard and its consumable gelpads and liners.
Advisors' Opinion:- [By Sean Williams]
Zeltiq Aesthetics (NASDAQ: ZLTQ )
Last, but certainly not least, we have Zeltiq Aesthetics, which utilizes its proprietary medical devices for the selective reduction of fat in patients. Understandably, we're not talking about a pharmacological solution here or even a long-term one necessarily. This is more of an aesthetic solution in cases where diet and exercise aren't meeting the patients' goal, but it should be noted that people will pay top dollar to look healthier and thinner, so Zeltiq's target audience is actually very large. - [By John Udovich]
On Tuesday, small cap biotech stock Kythera Biopharmaceuticals Inc (NASDAQ: KYTH) surged around 25% after announcing that its ATX-101 REFINE-1 and REFINE-2 Phase III trials met all primary and secondary endpoints for the reduction of so-called double chins; but if investors missed out on that rally, small caps Zeltiq Aesthetics Inc (NASDAQ: ZLTQ), Solta Medical Inc (NASDAQ: SLTM) and Cynosure, Inc (NASDAQ: CYNO) each have a piece of the aesthetic market as well. In the case of Kythera Biopharmaceuticals, its ATX-101 can be injected to deal with double chins���meaning its less invasive than liposuction as the drug dissolves fat cells but leaves other tissue alone. JP Morgan has noted:
- [By CRWE]
ZELTIQ Aesthetics, Inc. (Nasdaq:ZLTQ), a medical technology company focused on developing and commercializing products utilizing its proprietary controlled-cooling technology platform, together with the Massachusetts General Hospital (MGH), reported that the Mercantile Court in Spain on May 4 ruled in their favor regarding the patent infringement lawsuit jointly filed in Spain against Clinipro and Aquaestetica, its Spanish distributor.
- [By Jake L'Ecuyer]
ZELTIQ Aesthetics (NASDAQ: ZLTQ) was also up, gaining 6.92 percent to $18.76. Stifel Nicolaus initiated coverage on the stock with a Buy rating and a $28.00 price target.
Top 5 Forestry Companies To Buy For 2014: PowerShares WilderHill Clean Energy Portfolio (PBW)
PowerShares WilderHill Clean Energy Portfolio (the Fund) is based on the WilderHill Clean Energy Index and seeks investment results that correspond generally to the price and yield (before the Fund�� fees and expenses) of that equity index. The sectors covered by the Fund include Energy-Alternate Sources, Semiconductors, Electrical Components and Equipment, Chemicals, Electric, Electronics, Computers, Auto Parts and Equipment, Biotechnology and Agriculture. PowerShares Capital Management LLC is the Fund's investment adviser.
PowerShares WilderHill Clean Energy Portfolio�� top 10 holdings include SunPower Corp., Class A, Echelon Corp., Cypress Semiconductor Corp., Cree, Inc., First Solar, Inc., OM Group, Inc., Universal Display Corp., KYOCERA Corp. ADR (Japan), Suntech Power Holdings Co., Ltd. ADR (Cayman Islands) and Applied Materials, Inc.
Advisors' Opinion:- [By Aaron Levitt]
A lack of profits and the reliance on government subsidies have made most stocks in the renewable energy category pretty poor performers over the years. Just check out the performance of the broad PowerShares WilderHill Clean Energy ETF (PBW). It has lost about 7.5% annually since its inception in 2005.
- [By Wall Street Sector Selector]
Another ETF which invests in the solar sector is the PowerShares WilderHill Clean Energy ETF (PBW). Although its holdings are not limited to the solar sector, its most significant holding is SunPower Corporation at 4.96% of the weight. Its number three holding is MEMC Electronic Materials at 3.42% of the weight. PBW's average trading volume is robust at over 400,000 shares per day. Its market cap is $135 million.
Top 5 Forestry Companies To Buy For 2014: Wasgau Produktions & Handels AG (MSH)
Wasgau Produktions & Handels AG is a Germany-based retailer and producer of food articles. The Company divides its business activities into the two main segments Wholesale and Retail. The Wholesale�� businesses include seven Cash and Carry markets for restaurateurs and wholesale customers, as well as commercial businesses of the holding company WASGAU Produktions & Handels AG, which are supported by its subsidiary WASGAU Dienstleistungs & Logistik GmbH, active within warehouse management and transportation. The Operations within the Retail segment are mainly carried out through Company�� subsidiaries WASGAU Metzgerei GmbH and WASGAU Baeckerei & Konditorei GmbH, which produce and supply its stores with a variety of meats and bakery products, respectively. As of December 31, 2011, the Company operated through 24 affiliated companies and subsidiaries located in Germany. Advisors' Opinion:- [By Rex Crum]
The action helped push the Nasdaq (COMP) �up by 14 points to close at 3,943. The Philadelphia Semiconductor Index (COMP) �rose 0.4% and the Morgan Stanley High-Tech Index (MSH) �also closed with a small gain.
- [By Benjamin Pimentel]
The Nasdaq Composite Index (COMP) �eked out a 0.1% gain to close at 3,922. The benchmark ended the week down 0.5%. The Morgan Stanley High Tech 35 Index (MSH) �was also up a fraction, while the Philadelphia Semiconductor Index (SOX) �fell 0.3%.
- [By Benjamin Pimentel]
The Morgan Stanley High Tech 35 Index (MSH) �fell 0.3%, while the Philadelphia Semiconductor Index (SOX) �rose 0.4%.
- [By Benjamin Pimentel]
The Nasdaq Composite Index (COMP) �gave up 6 points to close at 4,352. But the benchmark ended the week up 1%. The Morgan Stanley High Tech 35 Index (MSH) �also was down a fraction on Friday, while the Philadelphia Semiconductor Index (SOX) was up 0.7%.
Top 5 Forestry Companies To Buy For 2014: Arcos Dorados Holdings Inc (ARCO)
Arcos Dorados Holdings Inc., incorporated on December 9, 2010, is a McDonald�� franchisee. As of December 31, 2010, the Company operated or franchised 1,755 McDonald��-branded restaurants, which represented 6.7% of McDonald�� total franchised restaurants globally. It operates McDonald��-branded restaurants under two different operating formats, Company-operated restaurants and franchised restaurants. As of December 31, 2010, of its 1,755 McDonald��-branded restaurants in the territories, 1,292 (or 74%) were Company-operated restaurants and 463 (or 26%) were franchised restaurants. It generates revenues from two sources: sales by Company-operated restaurants and revenues from franchised restaurants, which consist of rental income, which is based on the greater of a flat fee or a percentage of sales reported by franchised restaurants. As of December 31, 2010, it owned the land for 510 of its restaurants (totaling approximately 1.2 million square meters) and the buildings for all but 12 of its restaurants. It divides its operations into four geographical divisions: Brazil; the Caribbean division, consisting of Aruba, Curacao, French Guiana, Guadeloupe, Martinique, Puerto Rico and the United States Virgin Islands of St. Croix and St. Thomas; North Latin America division (NOLAD), consisting of Costa Rica, Mexico and Panama, and South Latin America division (SLAD), consisting of Argentina, Chile, Colombia, Ecuador, Peru, Uruguay and Venezuela. As of December 31, 2010, 35.1% of its restaurants were located in Brazil, 29.7% in SLAD, 27.1% in NOLAD and 8.1% in the Caribbean division. The Company conducts its business through its indirect, wholly owned subsidiary Arcos Dorados B.V.
Company-Operated and Franchised Restaurants
The Company operates its McDonald��-branded restaurants under two basic structures: Company-operated restaurants operated by the Company and franchised restaurants operated by franchisees. Under both operating alternatives the real estate location may ! either be owned or leased by the Company. It owns, fully manages and operates the Company-operated restaurants and retains any operating profits generated by such restaurants, after paying operating expenses and the franchise and other fees owed to McDonald�� under the Master Franchise Agreements (MFAs). In Company-operated restaurants, it assumes the capital expenditures for the building and equipment of the restaurant and, if it owns the real estate location, for the land as well. Under its franchise arrangements, franchisees provide a portion of the capital required by initially investing in the equipment, signs, seating and decor of their restaurants, and by reinvesting in the business over time. It is required by the MFAs to own the real estate or to secure long-term leases for franchised restaurant sites. It subsequently leases or subleases the property to franchisees.
In exchange for the lease and services, franchisees pay a monthly rent to the Company, based on the greater of a fixed rent or a certain percentage of gross sales. In addition to this monthly rent, it collects the monthly continuing franchise fee, which generally is 5% of the United States dollar equivalent of the restaurant�� gross sales, and pays these fees to McDonald�� pursuant to the MFAs. However, if a franchisee fails to pay its monthly continuing franchise fee, it remains liable for payment in full of these fees to McDonald��. As of December 31, 2010, it was engaged in several joint ventures, which collectively owned 24 restaurants, in Argentina, Chile and Colombia.
Restaurant Categories
The Company classifies its restaurants into one of four categories: freestanding, food court, in-store and mall stores. Freestanding restaurants are the type of restaurant, which have ample indoor seating and include a drive-through area. Food court restaurants are located in malls and consist of a front counter and kitchen and do not have their own seating area. In-store restaurants are part ! of a larg! er building and resemble freestanding restaurants, except for the lack of a drive-through area. Mall stores are located in malls like food court restaurants, but have their own seating areas. As of December 31, 2010, 808 (or 46.2%) of its restaurants were freestanding, 359 (or 20.5%) were food court, 265 (or 15.1%) were in-stores and 319 (or 18.2%) were mall stores. In addition, it has four non-traditional stores, such as food carts.
Reimaging
As of December 31, 2010, the Company had completed the reimaging of 308 of 1,569 restaurants. Many of the reimaging projects include the addition of McCafe locations to the restaurant. It has developed system-wide guidelines for the interior and exterior design of reimaged restaurants.
McCafe Locations and Dessert Centers
McCafe locations are stylish, separate areas within restaurants where customers can purchase a range of customizable beverages, including lattes, cappuccinos, mochas, hot and iced premium coffees and hot chocolate. As of December 31, 2010, there were 267 McCafe locations in the Territories, of which 12% were operated by franchisees. Argentina, with 71 locations, has McCafe locations, followed by Brazil, with 67 locations. In addition to McCafe locations, it has Dessert Centers. Dessert Centers operate from existing restaurants, but depend on them for supplies and operational support. As of December 31, 2010, there were 1,306 Dessert Centers in the Territories.
Product Offerings
The Company�� menus feature three tiers of products: affordable entry-level options, such as its Big Pleasures, Small Prices or Combo del Dia (Daily Extra Value Meal) offerings, core menu options, such as the Big Mac, Happy Meal and Quarter Pounder, and premium options, such as Big Tasty or Angus premium hamburgers and chicken sandwiches and low-calorie or low-sodium products, which are marketed through common platforms rather than as individual items. These platforms can be based on the ty! pe of pro! ducts, such as beef, chicken, salads or desserts, or on the type of customer targeted, such as the children�� menu.
Advisors' Opinion:- [By Seth Jayson]
Arcos Dorados Holdings (NYSE: ARCO ) is expected to report Q1 earnings on April 30. Here's what Wall Street wants to see:
The 10-second takeaway
Comparing the upcoming quarter to the prior-year quarter, average analyst estimates predict Arcos Dorados Holdings's revenues will grow 4.4% and EPS will decrease -58.3%. - [By Dan Caplinger]
Next Tuesday, Arcos Dorados (NYSE: ARCO ) will release its latest quarterly results. The key to making smart investment decisions on stocks reporting earnings is to anticipate how they'll do before they announce results, leaving you fully prepared to respond quickly to whatever inevitable surprises arise. That way, you'll be less likely to make an uninformed knee-jerk reaction to news that turns out to be exactly the wrong move.
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